Effects of mercury and lead on sperm
It has been documented that lead can cause a wide range of adverse reproductive outcomes. In men, lead can reduce the libido and affect spermatogenesis reducing the quality of sperm. Other effects in exposed men include disturbance of prostatic function and damage in serum testosterone. In pregnant women, lead can cross the placenta and impair the development of the fetus. Therefore, exposed women are at risk of suffering spontaneous abortion, premature delivery, gestational diabetes mellitus, pregnancy hypertension, preeclampsia, premature rupture of membranes, intrauterine growth restriction, low weight birth, and other pregnancy complications. In both men and women, lead has been associated with infertility.
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Effects of Lead on Reproductive Health
Try out PMC Labs and tell us what you think. Learn More. Several animal studies indicate that mercury is a male reproductive toxicant, but human studies are few and contradictory. We examined semen characteristics and serum levels of reproductive hormones in relation to environmental exposure to mercury.
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A significant increase in the incidence of male infertility has been described in the international literature, raising questions about its causes. Part of this effect may result from synthetic toxic substances acting on the endocrine system endocrine disruptors , many of which are routinely used in work processes. We provide a critical review of the specialized literature on work-related chemical substances capable of causing male infertility. Pesticides such as DDT, linuron, and others, heavy metals like mercury, lead, cadmium, and copper, and substances from various industrial uses and residues such as dioxins, polychlorinated biphenyls PCBs , ethylene dibromide EDB , phthalates, polyvinyl chloride PVC , and ethanol are among the main endocrine disruptors that can cause male infertility.
Try out PMC Labs and tell us what you think. Learn More. Methods: creatine kinase was isolated from human sperm homogenates after chromatography on a DEAE cellulose column.
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